OrganOx metra®
The World’s First Normothermic Machine Perfusion (NMP) Platform
This Changes Everything.
OrganOx metra® has already changed transplantation for the liver.1
Now, it’s the foundation of a platform that aims to transform the entire field of organ technology.
Every Organ is a Life-Saving Opportunity
The OrganOx metra platform extends organ preservation time,2 giving clinicians a longer window and more options to make better use of donor pools. Extending the length of time an organ is perfused enables clinicians to perform a more in-depth functional assessment on it, which can help lead to better outcomes.
OrganOx metra can help
OrganOx metra for Liver
With its multiple advanced automation features, our flagship product maintains perfusion conditions with an ease, consistency, and predictability that frees transplant surgeons to focus on the surgery itself.
How It Works
With the OrganOx metra, the donor liver is continuously perfused with oxygenated blood-based perfusate, medications, and nutrients at normal body temperature and near-physiological pressures and flows. Keeping the liver functional throughout preservation enables a more informed and accurate assessment of its viability for transplant.
Centrifugal Pump
A centrifugal pump draws blood from the liver, intelligently adjusting to physiological changes to ensure optimal perfusion.
Oxygenator
A self-regulating oxygenator receives oxygen that has been concentrated from ambient air, which it transfers into the blood-based perfusate while it is warmed by an on-board heater.
Perfusate Reservoir
A soft-shell reservoir stores the warm, oxygenated blood-based perfusate and supplies it to the liver under near-physiological pressure.
Blood Gas Analyzer
In-line blood gas analysis provides real-time monitoring of pO2, pCO2, pH and temperature.
Medication Infusion Driver
A syringe infusion driver delivers insulin, heparin, bile salts and epoprostenol. Infusions are delivered automatically, at a fixed rate, to provide continuous infusion throughout and help minimize the operator’s hands-on time.
Nutrition Pump
A mini roller pump can deliver a nutrition solution, or TPN, in response to user-measured glucose values.
Touchscreen
An easy-to-use touchscreen provides real-time pO2, pCO2, pH values and other perfusion information at a glance throughout the procedure.
Explore OrganOx metraProfessor James Shapiro
University of Alberta, Edmonton, Canada
The Future of Organ Technology Starts Here
OrganOx metra is approved for use in liver transplants across Europe, the United States, Canada, and Australia, and its safety and effectiveness is supported by ample clinical evidence.3,6,7
OrganOx metra has already supported the transplantation of over 5,000 livers worldwide, and that number continues to grow as its availability rapidly expands into new markets.
From Our Newsroom
Keep up to date with the latest OrganOx updates and recent news in organ transplantation.
- Ravikumar, R., Jassem, W., Mergental, H., Heaton, N., Mirza, D., Perera, M. T. P. R., & Friend, P. J. (2016). Liver transplantation after ex vivo normothermic machine preservation: A phase 1 (first-in-man) clinical trial. American Journal of Transplantation, 16(6), 1779–1787. https://doi.org/10.1111/ajt.13741.
- OrganOx Ltd. (2024). OrganOx® metra® instructions for use (USA version, Rev05). OrganOx Ltd. https://sites.google.com/view/2tyshpvxatbpbjgs7bff6bs7nturpw/na-ifu?authuser=0
- Mergental, H., Laing, R. W., Kirkham, A. J., Perera, M. T. P. R., Boteon, Y. L., Attard, J., Barton, D., Curbishley, S., Wilkhu, M., Neil, D. A. H., Hübscher, S. G., Muiesan, P., Isaac, J. R., Roberts, K. J., Abradelo, M., Schlegel, A., Ferguson, J., Cilliers, H., Bion, J., Adams, D. H., … Mirza, D. F. (2020). Transplantation of discarded livers following viability testing with normothermic machine perfusion. Nature communications, 11(1), 2939. https://doi.org/10.1038/s41467-020-16251-3
- Olumba, F. C., Zhou, F., Park, Y., Chapman, W. C., & RESTORE Investigators Group (2023). Normothermic Machine Perfusion for Declined Livers: A Strategy to Rescue Marginal Livers for Transplantation. Journal of the American College of Surgeons, 236(4), 614–625. https://doi.org/10.1097/XCS.0000000000000555
- Wehrle, C. J., Hong, H., Gross, A., Liu, Q., Ali, K., Cazzaniga, B., Miyazaki, Y., Tuul, M., Modaresi Esfeh, J., Khalil, M., Pita, A., Fernandes, E., Kim, J., Diago-Uso, T., Aucejo, F., Kwon, D. C. H., Fujiki, M., Quintini, C., Schlegel, A., Pinna, A., … Hashimoto, K. (2024). The impact of normothermic machine perfusion and acuity circles on waitlist time, mortality, and cost in liver transplantation: A multicenter experience. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 10.1097/LVT.0000000000000412. Advance online publication. https://doi.org/10.1097/LVT.0000000000000412.
- Wehrle, C. J., Zhang, M., Khalil, M., Pita, A., Modaresi Esfeh, J., Diago-Uso, T., Kim, J., Aucejo, F., Kwon, D. C. H., Ali, K., Cazzaniga, B., Miyazaki, Y., Liu, Q., Fares, S., Hong, H., Tuul, M., Jiao, C., Sun, K., Fairchild, R. L., Quintini, C., … Schlegel, A. (2024). Impact of Back-to-Base Normothermic Machine Perfusion on Complications and Costs: A Multicenter, Real-World Risk-Matched Analysis. Annals of surgery, 280(2), 300–310. https://doi.org/10.1097/SLA.0000000000006291
- Nasralla, D., Coussios, C. C., Mergental, H., Akhtar, M. Z., Butler, A. J., Ceresa, C. D. L., Chiocchia, V., Dutton, S. J., García-Valdecasas, J. C., Heaton, N., Imber, C., Jassem, W., Jochmans, I., Karani, J., Knight, S. R., Kocabayoglu, P., Malagò, M., Mirza, D., Morris, P. J., Pallan, A., … Consortium for Organ Preservation in Europe (2018). A randomized trial of normothermic preservation in liver transplantation. Nature, 557(7703), 50–56. https://doi.org/10.1038/s41586-018-0047-9